Thursday, March 19, 2015
Exhibit Hall Poster Area 1 (Convention Center)
Songtao Wang1, Xizhou Wang2, Yanyan Sun1 and Lin Jia3, (1)South China Normal University, Guangzhou, China, (2)LanZhou University, LanZhou, China, (3)Shenyang Exit-Entry Inspection and Quarantine Bureau, Shenyang, China
Background/Purpose: The enteric nervous system (ENS) is one of the main divisions of the autonomic nervous system (ANS) and consists of a mesh-like system of neurons that governs the function of the gastrointestinal system
[1]. ENS’ dysfunction has a close relationship with many gastrointestinal diseases and other healthy question, such as inflammation, diarrhea, constipation, irritable bowel syndrome, diabetes, and obesity
[2,3,4]. Proper exercise can improve the function of gastrointestinal tract
[5], but its microscopic structure and mechanism is not clear, especially about the effect of exercise on ENS and its relationship with health. Thus this study discussed the effect of aerobic exercise on the gastrointestinal function based on the ENS, through the observation and analysis of the gastrointestinal function, intestinal innervations and distribution, as well as SP and VIP nerve remodeling. This study will help to enrich and develop the relative theories about exercise and autonomic nerve system, and to clarify the autonomic nervous mechanism of exercise for weight loss, and related gastrointestinal disorders.
Method: 16 adult male SD rats were randomly divided into 2 groups: control group (C) and exercise group (E). The E group was subjected to a moderate swimming exercise program for 10 weeks (6 times/week, 1h/ times). Intestinal motility and absorption function were measured and the colonic neurons were quantified using immunofluorescence (PGP 9.5, VIP and SP).
Analysis/Results: Compared with group C, the relative testing index of group E showed the following changes: the intestinal muscle fiber arranged regularly and closely, and the circinate muscle and mucous layer thicken obviously; The intestinal propulsion and absorption rate of D- xylose were significantly up-regulated (P<0.01 and P<0.05); The positive expression of PGP9.5 raised (P<0.05); And the amount of VIP positive neurons increased (P<0.05), but the SP expression decreased (P<0.05).
Conclusions: Regular moderate intensity exercise can enforced the intestinal motility and absorption function, which can be partly explained by increasing intestinal neural distribution and innervations, up-regulating VIP neurons expression, down-regulating SP neurons expression, and the shifting balance of excitability and inhibitory in ENS. All the above changes in ENS may help to promote the nutrition absorb in aerobic exercising body.
