Evidence-based decision and practice has been broadly adopted and promoted in many fields now, but procedures/frameworks on how to collect and determine the evidence were often not well described. This presentation is to introduce the appropriate procedure to collect and determine the evidence, with an emphasis on analytic tools. Commonly used evidence-determination procedure was developed by the process invented by Guyatt et al. (1992), but it has often been modified when it is applied to a specific field, such as public health (Brownson et al., 1999, 2003), behavioral science (Deegear & Lawson, 2003; Nathan, 1998), nursing (Pravikoff & Pierce, 2003), and psychotherapy (Sanderson, 2004). Although there are some variations among these procedures, they shared the same general principle of scientific reasoning. These procedures can be summarized into five major steps: (a) Develop a statement of the issue, (b) Identify the relevant evidence, (c) Quantify the issue, (d) Determine the best course of action, and (e) Evaluate process and outcomes (Brownson et al., 1999, 2003; Kohatsu et al., 2004). A number of existing or new quantitative and qualitative methods (e.g., experimental trial, meta-analysis, surveillance, expert panel conference and observational study) have been integrated into the evidence determination process (Atkins et al., 1998; Boulware et al., 2001; Brownson et al., 1999). Meta-analysis is a good quantitative method example in synthesizing the findings of multiple research studies and has played a critical role in progressing evidence-based research. Expert panel conference, on the other hand, has also found a successful way of getting evidence as a qualitative approach. After providing an overview of major steps of the procedures and characteristics of key quantitative and qualitative methods, a step-by-step example will be illustrated on how to collect and determine evidence for health behaviors research. Keyword(s): measurement/evaluation, safety/injury prevention, standards and ethics