Purpose: The purpose of this study was to identify the principal risk factors associated with development of selected chronic diseases, and develop targeted educational strategies designed to prevent and/or control these diseases among adults who seek health services from a selected hospital in Cuidad Juárez, Chihuahua, Mexico. Significance: Hypertension is a major chronic disease that has a social and economic impact in Mexico. Much of this is associated with being overweight, a condition that affects an estimated 34% of the adult population over age 24 in Juárez. Unfortunately, the population is not fully aware of how this insidious disease can affect them. This study represents the seminal attempt to use community-based intervention strategies designed to address the major chronic disease causes of death in Juárez. Methodology: Eighty two individuals who sought health services at the selected hospital were randomly placed into two groups, experimental and control. Intervention strategies were adapted from a program initially developed at Stanford University. These strategies were modified to ensure cultural sensitivity for the study population in Juárez. The educational program was designed to cover six weeks, one time per week, 2 ˝ hours per session, for a total of 15 hours. What is unique is that the educational interventions were conducted in the homes of community residents with smaller groups of approximately 10 individuals per group. Four such groups were established, and presented with the educational program presented by health professionals, assisted by community Promotoras. Content included an explanation of hypertension and cardiovascular disease, risk factors associated with CV disease, nutrition, physical activity, the importance of regular medical checkups, treatment options, control of disease, and familial participation. The control group presented at the hospital where general health diagnostic tests were conducted. They were treated for adverse findings, but no educational interventions were presented. Findings: Following the intervention, the risk factors of obesity, hypertension, hyperglycemia, hypercholesterolemia, and hyperlipidemia all dropped significantly (p<.05) within the experimental group compared to the control group. Hypertension was reduced by 50% within the experimental group. Recommendations: Specifically targeted educational strategies conducted in the locale of those at risk can produce positive reductions in risk factors that may lead to reduced mortality within high risk populations. Programs designed to train hospital staff in the implementation of these programs that work should be undertaken as a part of the in-service program with hospitals and clinics.Keyword(s): community-based programs, disease prevention/wellness, health promotion