Purpose: The purpose of this study was to determine the knowledge and attitudes of selected college students about Human Papilloma Virus (HPV) and Cervical Cancer. Significance: This study represents a seminal effort to compare the knowledge and attitudes between college men and women about HPV and Cervical Cancer. Design: All students from five general university English classes (N=95) were selected for participation in the study. A previously used 42 item survey instrument was adapted and pilot tested for use with men and women in the present study. Psychometric quality of the instrument was determined through use of an expert panel as well as statistical analyses. The affective items were presented in a Likert format from Strongly Agree to Strongly Disagree. Negatively worded items were recoded such that the “best” affective response received a score of 5 and the least desirable affective response received a score of 1. Knowledge items were recoded such that 1 equaled a correct response and an incorrect, missing, or dual response was given a score of zero. Two null hypotheses guided the study; there would be no significant differences in either total knowledge or attitude scores of selected college students related to HPV and Cervical Cancer. Total knowledge and attitude scores were computed and compared using bivariate analyses. Comparisons between men and women for each item individually, as well as in total were conducted. Results: No significant difference in either total knowledge or attitude scores between men or women were identified, thus neither of the null hypotheses was rejected. Students in this population did not perceive themselves to be susceptible to HPV. There was a positive correlation between total knowledge and attitude scores within the study population. Women were more likely than men to know individuals who had obtained a pap smear, who should get a pap smear, and were less likely to believe that only women could be diagnosed with HPV. Over 60% indicated they were currently sexually active. Only 5% of this group indicated they did not use a method of contraception the last time they had sexual intercourse, 14% indicated they had used condoms, 12% used birth control pills, and 17% indicated use of a combination of condoms and birth control pills. The data from this study will be used to develop educational programs within the student health service specifically targeted to address misconceptions held by the students.Keyword(s): disease prevention/wellness, health education college/univ, research