Many universities and colleges offer a required health-related fitness course with the goal of eliciting positive behavioral changes. Though numerous studies have addressed the effectiveness of such courses on health behavior change, less is known regarding the potential of the educational intervention to modify the mediators of health behavior outcomes. Therefore, the purpose of this study was to determine if the required health-related fitness course garnered a change in self-reported social support, perceived barriers to exercise, and exercise confidence. Data were collected from 1136 subjects that were categorized into two groups: (control), students not exposed to the health-related fitness course and (experimental), students enrolled in the course. A major goal of the health-related fitness course was to promote positive physical activity patterns using behavioral change strategies such as goal setting and assessment, peer group strategy and re-enforcement, and the development of personalized exercise prescriptions. Subjects responded to three sets of Likert scale type questions before and after the 15-week intervention. The data were analyzed using Chi-Square tests. In terms of social support from friends, the health-related fitness course elicited a 6.5% increase (p<.05), in the number of subjects reporting that friends gave them helpful reminders to be physically active more often. There was a 5.7% increase in the number reporting their friends gave them rewards for being physically active, and a 6.0% increase of those reporting their friends helped them plan events around physical activities. In terms of perceived barriers to exercise, there was a 13% increase (p<.05) in the number who reported they strongly disagreed or disagreed that exercise was not one of their priorities. Regarding exercise confidence, no significant differences were found between the experimental and control groups. In conclusion, the health-related fitness course potentially had a small effect on social support, and little or no effect on barriers to physical activity and exercise confidence. Therefore, it would be prudent to incorporate additional educational strategies designed to reduce barriers to exercise and to foster exercise confidence.