An accurate understanding of the sexual knowledge, attitudes and behaviors of African Americans college students is crucial to education and intervention programs intended to address sexual health issues affecting this population. This study examines levels of sexual knowledge, sexual desire, sexual abuse and alcohol use among a sample of African American students (n = 224) attending a predominantly Black college. Students enrolled in junior level health sciences classes anonymously completed an 83-item questionnaire containing scales for sexual knowledge, sexual desire, sexual abuse, and alcohol use. Data were analyzed by personal computer using SPSS-11.0. A history of sexual abuse was reported by 11% of the sample (n = 24) with females more likely to report abuse than males (p < .047); sexual desire values were above normal for 4% (n = 10) of the sample, within normal for 89% (n = 198), borderline for 6% (n = 13), and hypoactive for 1% (n = 3). Alcohol abuse was detected in 10% (n = 22) of the sample. Those sexually abused had higher knowledge scores (p < .014) and were more likely to abuse alcohol (p < .001) than the non-abused but did not differ by sexual desire. In general, sexual knowledge did not differ from normative samples of college students. The findings indicate African American students are similar to other students in sexual knowledge, sexual desire, and rates of sexual abuse. Keyword(s): health promotion, multiculturalism/cultural diversity, wellness/disease prevention