This study compared Personal Action Toward Health™(PATH™), an audio-delivered program, and the American Lung Association’s Freedom From Smoking self-help manual, both integrated with use of a Telephone Survey System (TSS) to promote self-monitoring. The PATH™ program and FFS manual contain cognitive-behavioral and Stage of Change derived smoking cessation techniques and educational components, which have broad empirical and clinical support in the self-management and self-change literature. Twenty smokers (mean age 52.6, mean years education 12.7, 75% female, 50% African American, 65% below poverty status, 60% with more than 30 years smoking), recruited exclusively from an urban, faith-based health center serving the working poor and uninsured, were randomly assigned to two treatment conditions. Movement in stages of change and abstinence data were collected at 3-, 6- and 12-months post treatment onset. By 6 and 12-month follow-up the PATH program achieved clinically superior verified one-month continuous abstinence rates, 20% versus 10% respectively, favoring the PATH program (6 month comparison; Chi square = 2.222, df = 1, p = .136). The lack of statistical significance appears due to the small sample size. The achieved abstinence rates are noteworthy, given the number of risk factors this population demonstrates for continued smoking. The most effective method for engaging potential project enrollees was personalized recruitment letters, with 80 % of the individuals responding to letters converted to enrollees, whereas those responding to other materials (e.g., posters) enrolled only at a 49% rate (Chi square= 5.939, df = 1, p = .015). The fact that the number of strengths reported for the Audio and Manual programs (17) outweighed the reported weaknesses (4) support the notion that self-guided smoking cessation is a palatable method of program delivery for a population served by an urban faith-based health center.