Reports regarding the effects of multiple versus single-set strength training regimens are numerous and the general consensus is that the two regimens produce similar gains in strength. This project explored the issue by manipulating the sequence of exercises within the multiple set regimens. Since early strength gains are associated more with neural adaptations than muscle hypertrophy, multiple set regimens may differentially optimize training stimuli for the nervous system and influence strength gains. Forty-two untrained participants (Mean age=20.1 + 1.9 years) were randomly assigned to one of four regimens of strength exercises. Three regimens were variations of a multiple set protocol (alternating, blocked, and semi-blocked) while the fourth was a single-set protocol. All multiple set regimens involved six sets of 10 repetitions. The single set participants performed to exhaustion. The alternating regimen required performing one set of curls, lateral raises, and triceps extensions with the sequence repeated six times. In the blocked regimen the participants perform all sets of each exercise before performing the next. The semi-blocked regimen involved three consecutive sets of each exercise with the sequence repeated twice. Each exercise repetition was completed in 2s, with 45s rest between sets. Participants were pretested with the 3-5 RM protocol from which the 1RM value was then mathematically derived. Sixty-five percent of this value was the initial weight lifted. Gains in strength from pre-test to posttest, also assessed with the 3-5 RM test, were recorded and used in the analysis. Additional assessments included anthropometric measurements of the brachial and forearm regions of the participants’ dominant arms. Data from the posttests were analyzed with a 4 x 3 (Schedule x Test) one-way ANOVA. A significant group difference, F (3,38)=2.984, p < .05, was obtained on the biceps curl posttest. Post hoc analysis (Tukey’s HSD) revealed that Blocked group improved significantly more than the Single-set group. No other group comparisons on the posttests were significant. The anthropometric data were analyzed with a 4 x 2 (Schedule x Measurement) one-way ANOVA. There were no significant group differences. Discussion centers on the possible advantages of the blocked regimen and how it led to greater strength development on the biceps curl.