Osteoporosis is major public threat for 25 million Americans, (80% female). The purpose of this case study was to determine the efficacy of strength training and nutritional interventions in the treatment of osteoporosis in a healthy (PM) woman utilizing minimal pharmacological therapy. The subject was a 53 year old, nonsmoking PM woman in general good health. Pharmacological therapy consisted of estradiol (1 mg/d)+ Provera daily since 1991. Dual Energy X-ray Absorbometry (DEXA) was utilized to determine the subject’s bone health. DEXA was performed during three medical examinations in 1996, 1998, and 2000. The initial DEXA scan, (1996) was positive for the diagnosis of osteoporosis (spine: 0.76 g/cm2 z=- 3.6; hip: 0.73 g/cm2 z=-2.1). At that time, the subject’s exercise regime was limited to intermittent physical activity consisting primarily of cardiovascular exercise (e.g., walking/ jogging 30 minutes daily). FOXAMAX (10 mg/d) was prescribed by the subject’s physician. The second DEXA scan (1998) revealed increased degeneration of the hip: 0.67 g/cm2 z=-2.6). No changes were reported in the bone density of the spine. Under the direction of Exercise Science Student Interns, the subject then began participation in a 4-day per week strength training regime consisting of upper and lower body exercises that included, push-ups, sit-ups and 3 sets of 8-12 repetitions of the following weight training exercises: (a) chest press, (b) lat pull down, (c) bicep curls, (d) leg press, (e) leg curls, and (f) leg extensions. These exercises were performed with a combination of barbell, dumbbell, and Universal machine routines at 80% of the subject’s one repetition maximum. The subject’s participation in cardiovascular exercise continued in type and duration (i.e., walking/jogging 30 minutes) but was increased in frequency to 5 times weekly. The subject also consumed 1000 mg of calcium daily. FOXAMAX was discontinued due to esophageal spasms. In the 2000 DXA scan, increases were observed in both the spine and hip measurements (spine: 0.81 g/cm2 z=- 3.2; hip: 0.70 g/cm2 z=-2.3). These changes represented a 9% increase in Bone Mineral Density (BMD) of the lumbar spine and a 5% increase in BMD of the hip. When compared to 1998 data, these increases were considered physiologically and medically significant. These findings support the National Institute of Health (NIH, 2000) position that lifestyle changes, including salutary modifications of exercise and diet may be more effective than purely pharmacological treatment interventions for osteoporosis.