Considerable research has indicated that aging is typically associated with a decline in cardiovascular function. Because the declines in cardiovascular function are so prevalent, the topic of cardiovascular aging has created considerable interest among researchers. However, the extent of aging effects on cardiovascular function varies across selected studies. This meta-analytic study quantitatively determined the effects of aging and several specific experimental characteristics on cardiovascular function of seniors. After searching database and reference lists, effect sizes (ESs) for maximal oxygen consumption (VO2 max), heart rate (HR), and blood pressure (BP) were calculated from 48 studies that met the specific criteria of inclusion (379 ESs, 2,029 participants, 1210 males and 819 females, from 57 to 79 years of age). Descriptive data indicated that the overall aging effects on the three cardiovascular measures (Vo2 max, HR, and BP) is substantial (mean weighted ES=1.569) and support the hypothesis that aging results in a decrease in cardiovascular function. Validity of experiment, gender and exercise status of the participants, type of dependent measures, and funding status of research were identified as moderator variables for the aging effects on cardiovascular function. Specifically, studies with weak experimental validity demonstrate higher aging effects (ES=1.99) than those with moderate or high experimental validity (ES=0.833). Female participants demonstrate a greater aging deterioration (ES=2.588) than their male counterparts (ES=1.146). Participants who habitually take part in exercise or physical activity reveal a smaller aging deterioration (ES=1.752) than their sedentary counterparts (ES=1.983). In addition, research using the variables of Vo2 max and HR shows greater aging effects on cardiovascular function (ES=1.853 and 1.830) than research using the variable of BP (ES=0.807). Finally, research that received funding demonstrates smaller aging effects (ES=0.889) than research that did not report the funding status (ES=2.641). These data suggest that the variation in the effects of aging on cardiovascular function (ESs) is related to the experimental characteristics of the studies. The information from this meta-analysis raises concerns regarding future experimental design and interpretation of research results in this area.