Calcium ß-hydroxy ß-methylbutyrate (HMB) has been marketed as a nutritional supplementation that reduces whole body catabolism and promotes gains in strength for individuals interested in enhancing fitness parameters. However, the effects of HMB supplementation on strength alterations have not been examined closely in the current research. Therefore, the purpose of this study was to determine the effectiveness HMB as a useful ergogenic supplement for untrained college-aged males that seek maximal increases in strength during resistance training. In a double-blind and randomized manner, 18 college-aged males were matched-paired according to body weight and assigned to one of three groups to supplement their diet for six weeks with a carbohydrate placebo control (3g/day), or HMB (1.5g/day), or HMB (3g/day) while performing a resistance-training regimen three times a week. The following were recorded prior to and following the study: 1RM bench press (BP), Control Pre=165± 21.21; Post=180±28.28; HMB 1.5g/day, Pre=144±27.02, Post=166±39.74; HMB 3g/day, Pre=141.67±45.79, Post=171.67±46.22, and 1RM leg press (LP), Control Pre=220±57.27; Post=260±49.73; HMB 1.5g/day, Pre=256±46.76, Post=296±53.67; HMB 3g/day, Pre=233.33±46.90, Post=273.33±46.76. Results revealed no significant group x time interaction effect for BP (p=. 319). For pre-post weight lifted in 1RM BP there was a significant main effect (Wilks' L=.228, F1, 10=33.854, p=. 000). Results were similar for the LP (Wilks' L=.161, F 1, 10=51.923, p=.000). The results indicate that six weeks of HMB supplementation (1.5g/day or 3g/day) during resistance training by untrained college-aged males had no effect on upper body strength and lower body strength. Because of the limited research, it is recommended that additional studies should be conducted to evaluate the effects of HMB supplementation at varying doses on strength in untrained subjects for longer training periods. Keyword(s): exercise/fitness, performance, physical activity