This study examined specific health behaviors within the general categories of unintentional injuries and violence, tobacco use, alcohol and other drug use, sexual behavior, dietary behavior, and physical activity of students attending Edinboro University of Pennsylvania (EUP). The health behaviors of EUP students who had declared health and physical education (HPE) as a major was compared to EUP students who had declared a major from another program of study. Results were used to obtain baseline data to determine the influence of program of study on health risk behaviors among EUP students and to examine the effect that age, gender, and class standing had on health behavior. The National College Health Risk Behavior Survey, a self-report questionnaire developed by the Centers for Disease Control and Prevention, was administered to 489 undergraduate students who were enrolled at EUP during the spring 2004 semester. Of the participants, 39.3% (192) were majoring in health and physical education, and 60.7% (297) were non HPE majors. Analysis of the data consisted of frequency tables, and category means. In addition, one-way analysis of variance (ANOVA) and chi square were computed to determine if a significant relationship existed between the independent and dependent variables. Results indicated that Edinboro University of Pennsylvania HPE majors engaged in health behaviors that place them at high risk for increased morbidity and mortality, especially in the areas of alcohol consumption, binge drinking and unprotected sexual activity. Non majors exhibit high risk behavior in the areas of binge drinking, smoking, lack of physical activity, and unprotected sexual activity. Recommendations for further research include administering the NCHRBS throughout the other thirteen universities of the Pennsylvania State System of Higher Education and other institutions of higher education. This would permit an accurate, comprehensive examination of the priority health behaviors of college students in Pennsylvania. It is also recommended to replicate the study at EUP every three years to evaluate the effectiveness of curricular revision and programming efforts. Keyword(s): college level issues, research, wellness/disease prevention