Purpose: Religion and spirituality have been shown to be important social and psychological factors in the lives of adults, but less effort has been devoted to the study of these factors and their relationship to quality of life (QOL) among the pivotal college population. Increasing QOL is often referred to as the cornerstone of health promotion. This study aims to extend upon prior research in the area of spirituality and religiosity and its association to life satisfaction by 1) exploring the effects both religiosity and spirituality concurrently on 2) a valid and reliable measure of overall life satisfaction (N=522). Methods: A mediational model was tested between spirituality, religiosity, self-rated health, and a valid overall measure life satisfaction. Using methods outlined by Barron and Kenny (1986), mediational models were tested. Results: All evaluation criteria indicated well-fitting models for both the spirituality and religiosity models. The spirituality mediational model displayed excellent fit criteria, chi-square(n=459, 4) = 1.64, p=.80, CFI = .99, TLI=.99, as did the religiosity model, chi-square(n=459, 1) = 1.34, p=.25, CFI = .99, TLI=.99. We constrained the mediational model to be equal for both men and women, chi-square (n=459, 10) = 22.29, p=.01 CFI = .99, TLI = .99. Conclusion: Results indicate spirituality (and religiosity) and life satisfaction is mediated by self-rated health. These preliminary findings provide the first evidence that students who describe themselves as spiritual (or religious) are likely to report greater self-rated health and that greater self-rated health likely influences perceived life satisfaction for both men and women, which has implications for health promotion practice.