Abstract This study was generated to assess the behavior, knowledge, and attitudes among undergraduate students in Southern Illinois University at Carbondale. Respondents consisted of 50 male and female undergraduate students, who were studying at the Southern Illinois University at Carbondale. About 68% of the respondents (n=34) were female, and the remaining 32% were male students (n=16). The purpose of the study was to examine smoking behavior, knowledge, and attitudes among undergraduate students in the Southern Illinois University at Carbondale. Healthcare providers must be better informed about smoking behavior in this group of population.