OBJECTIVE: To examine ratings of satiety as they relate to weight gain, genetic admixture, and leptin. RESEARCH METHODS: The subjects included 56 premenopausal women; 30 of whom self-identified themselves as African-American (AA) and 26, as European-American (EA). Of these women, genetic admixture was obtained on 43 of the subjects; 15 of those self-identifying themselves as EA were 3.1±6.0 % African admixture and 28 of those self-identifying themselves as AA were 85.4±15.2 % African admixture. The mean age was 33.5± 4.8 and the mean BMI was 23.1± 1.4 kg/m2. Subjects were evaluated under diet controlled energy balanced conditions and underwent the following assessments: serum leptin levels; genetic admixture determination; body composition, using dual energy x-ray absorptiometry; and hunger-satiety evaluation performed before and one hour after breakfast. RESULTS: Satiety before breakfast (SBB) was significantly related to percent African admixture (r=0.32, p=0.03), serum leptin (r=0.31, p=0.02), and weight gain (r=-0.32, p=0.03). Simple correlations also indicated a trend between leptin and weight gain r=-0.30, p=0.07). After adjusting for the confounding effects of fat mass (FM) and fat-free mass (FFM) the relationships between SBB and admixture and weight gain remained significant (r=0.32, p=0.04; r=-0.33, p=0.03) and the relationship between SBB and leptin disappeared. A trend however, emerged between leptin and weight gain after making these adjustments (r=-0.28, p=0.07). CONCLUSIONS: The findings of this study indicate that when under energy balanced conditions, subjects with higher SBB ratings tended to gain less weight over the course of one year than those with lower SBB ratings. Also, these findings indicate that individuals with higher African genetic admixture tended to be more satiated before breakfast, and that there was an inverse trend between serum leptin and weight gain. A better understanding of mediating factors effecting satiety could be instrumental in weight gain management, particularly in African-Americans.