Tobacco use is the single most important preventable cause of death. Nearly 90% of adult smokers began smoking before age 18, with an average age of first cigarette of 11.5 years and average age of daily smoking by 14.5 years. Furthermore, recent surveillance data indicate increases in adolescent smoking, especially among certain demographic groups. Not only is adolescent tobacco use a substantial public health problem, the use of tobacco may be a visible marker for other health behaviors. The purpose of this study was to examine the relationship of adolescent tobacco use to other heath behaviors. Data for the study came from the Youth Risk Behavior Study conducted in Arkansas in 2001. This included data from 917 females and 772 males in grades 9-12. Data were analyzed using SAS programs to conduct frequency counts, perform chi-square analysis, factor analysis, and analysis of variance. Students who indicated that they had smoked cigarettes at least one time in the last month were classified as current smokers (n=530). Those who indicated that they had not smoked during the last month were classified as non-smokers (n=1,082). Smokers and non-smokers were compared on 70 different health behaviors in areas such as motor vehicle safety, weapon carrying, violence, suicide, alcohol and other drug use, sex, weight control/nutrition, and exercise. There were statistically (p<.05) significant differences between smokers and non-smokers for 60 of the behaviors. For each of these 60 behaviors, non-smokers were more likely to indicate engaging in the more healthy/desirable behavior. The 10 behaviors for which there were no differences were all related to either nutrition or exercise (though there were differences for some nutrition and exercise variables). Factor analysis was used to organize the individual behavior variables into more manageable factors including: steroid use, substance use, fruits and vegetable intake, exercise, weapon carrying, smokeless tobacco, fighting, sexual behavior, suicide, and weight concerns. Analysis of variance was used to compare smokers and non-smokers on the scores for each factor. Significant differences (p<.05) were found between smokers and non-smokers for steroid use, substance use, weapon carrying, smokeless tobacco, fighting, and sexual behavior. There was also a significant behavior x gender interaction for fruits and vegetable intake. Rsquare values for four of these six factors was between .145 and .195. Results indicate that youth tobacco use is linked to a number of other undesirable health behaviors. Results should be considered by those interested in adolescent prevention programming.Keyword(s): research, wellness/disease prevention, youth-at-risk