Significance: The purposes of the study were to: 1. evaluate effectiveness of school-based physical education intervention integrating exercise, health education and behavior modification on obesity and related health measures in urban teenagers, and 2. develop percentile tables for gender and ethnicity differences for all measures. Design: 555 girls (389 Exp v. 166 Con) and 324 boys (235Exp v. 89 Con) were compared pre to post 12 weeks intervention (PATH). Changes were compared with traditional sport skill physical education classes. Measurements included BMI, % body fat from skinfolds (BF), systolic (Sp) and diastolic (Dp) blood pressures, diet assessment (D), outside school physical activity (PA), total cholesterol (Ch), heart health knowledge (HK), and estimated maximal oxygen uptake (VO2). Significant pre to post-test within gender differences between experimental and control subjects were determined with independent t-tests and chi square analysis. Comparisons were also made between the most obese subjects, 85th and 95th percentiles, respectively. All statistical tests were run on version 10.0 of SPSS. Percentile tables were developed according to gender and ethnicity on all measures. The 0.05 level of significance was used. Results: When compared with traditional physical education females in PATH made significant improvements in subscapular (15.7 v. 14.2mm), suprailiac (19.4 v. 17.7mm), and total skinfolds (52 v. 48mm), BF (30 v. 28%), Sp (111 v. 105mmHg), Dp (71 v. 68mmHg), and HK (52 v. 56% correct responses). The most obese girls also showed significant improvement in VO2 (35 v. 37ml)2.kg.min). Boys in PATH displayed significant decreases in Dp (72 v. 70mmHg), and DH (48 v. 46 times/weeks intake of fat, salt, sugar), and increased HK (47 v. 53% correct responses). The most obese boys also demonstrated significant increases in PA (4.8 v. 6.3 times/week activity > 15 min), and decreases in dietary fat (34 v. 32 times/week intake), and DH (46 v. 44 times/week intake of fat, salt, sugar). Percentile tables displayed differences between genders and ethnic groups. PATH intervention led to significantly greater improvements in obesity and related heart health measures v. traditional sport skill physical education. Improvements were greater in girls than boys and were greatest in most obese girls and boys. Percentile rankings showed differences between genders and among ethnic groups.