Work-related safety and health issues are a major concern among the three million seasonal farmworkers who work in the U.S. agricultural industry. Though existing migrant health programs are designed to address the health needs of some of these farmworkers, these programs reach less than 20% of the seasonal farmworker population. Lack of insurance and cultural barriers among these individuals contribute to excessive use of hospital emergency rooms as a primary source of health care, a factor that exacerbates problems within the U.S. health care system. On-going research and follow-up health education efforts can be part of the solution to this problem if health promotion and efforts are specifically tailored to local needs and cultural perspectives. This NIOSH-funded study is part of on-going work in east Texas where little attention has been previously devoted to the health of seasonal farmworkers. This study was a follow-up to previous qualitative health assessments. In it, a quantitative survey instrument was developed, validated, and pilot tested through 300 face-to-face interviews of farmworkers who live and work in an 11-county area. Bilingual members of the community were recruited and trained to implement the surveys within a convenience sample recruited through local churches and health fairs. Data collected included information related to causes of work-related injuries (e.g., mishandling of equipment, falls); health conditions that result from unsafe exposure to chemicals, extreme temperatures, solar rays, etc; work-induced and work-affecting illnesses (e.g., cancer, respiratory illnesses); and other stress-related symptoms and behaviors (e.g., drug abuse) that can be exacerbated by the work environment. In addition, questions were also asked about how the respondents prevented and/or treated these injuries, illnesses, and stress-induced conditions. Subscale frequencies and multiple regression analyses were used to identify common injury and health risk factors and their interrelated associations. Among the factors that emerged as significant contributors to injuries and health conditions were language barriers (an inability to read English-speaking instructions and warning labels on chemicals/equipment, difficulty understanding verbal instructions from English-speaking employers), lack of formal safety training, low availability and use of safety equipment (e.g., goggles, gloves, masks), and lack of adequate early treatment of health conditions. Results were reported to NIOSH for dissemination to other organizations interested in the work-related health and safety of seasonal farmworkers. The information will be used to design future health education efforts within this population.